Must know adverse effects in Pharmacology

Agranulocytosis

Clozapine, Chloramphenical

• Chloramphenicol
• NSAIDs
•  Benzene

Atropine-like Side Effects

Tricyclics

Cardiotoxicity

Doxorubicin

 Daunorubicin

Cartilage Damage in Children

Fluoroquinolones (Ciprofloxacin & Norfloxacin)

Cinchonism

Quinidine

Cough

ACE Inhibitors

Disulfiram-like Effect

Metronidazole , Sulfonylureas (1st generation)

Extrapyramidal Side Effects

Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine)

Fanconi's Syndrome

Tetracycline

Fatal Hepatotoxicity (necrosis)

Valproic Acid, Halothane , Acetaminophen

Gingival Hyperplasia

Phenytoin

Gray Baby Syndrome

Chloramphenicol

Gynecomastia

Cimetidine, Azoles, Spironolactone, Digitalis, Isoniazid

Hemolytic Anemia in G6PD-deficiency

Sulfonamides, Isoniazid, Aspirin, Ibuprofen, Anti-malarial drugs, Dapsone

Hepatitis

• NSAIDS
• Anabolic steroids
• Birth control pills
• Chlorpromazine
• Erythromycin
• Halothane (a type of anesthesia)
• Methyldopa
• Isoniazid
• Methotrexate
• Statins
• Sulfa drugs
• Tetracyclines
• Amoxicillin-clavulanate
• Some anti-seizure medicines

Hot Flashes, Flushing

Niacin, Tamoxifen, Ca++ Channel Blockers

Induce CP450

Barbiturates, – Phenobarbital, Phenytoin, Carbamazepine, Rifampin

Inhibit CP450

Cimetidine, Ketoconazole

Interstitial Nephritis

Methicillin, NSAIDs (except Aspirin), Furosemide, Sulfonamides

Monday Disease

Nitroglycerin Industrial exposure → tolerance during week → loss of tolerance during weekend → headache, -

ach, dizziness upon re-exposure

Nephrogenic Diabetes Insipidus

Lithium (Txt w/ Amiloride)

Orange Body Fluids

Rifampin

Osteoporosis

Heparin Corticosteroids

Peptic Ulcer

NSAIDS, Corticosteroids, cytotoxic drugs. But NSAIDS are protective against colonic carcinoma.

Positive Coomb's Test

Methyldopa

Pulmonary Fibrosis

Bleomycin, Amiodarone

Red Man Syndrome

Vancomycin

SLE-like Syndrome

Hydralazine, INH, Procainamide (HIP)

Severe HTN with Tyramine

MAOIs

Tardive Dyskinesia

Antipsychotics (Thioridazine, Haloperidol, Chlorpromazine) Clozapine: only antipsychotic to not give you tardive dyskinesia

Tinnitus

Aspirin, Quinidine

Thrmobocytopenia

Quinine, Quinidine, Vancomycin, Heparin

Megaloblastic Anemia

Phenytoin, Primadone, B12 and folic acid defeciencies, Alchohol, Trimethoprim, Sulfasalazine, Metformin, Antifolates (Methotrexate), N2O